Cetirizine; Pseudoephedrine (Zyrtec-D) Indications and Dosage
- allergic rhinitis
- nasal congestion
Cetirizine; Pseudoephedrine (Zyrtec-D) Indications and Dosage
For the treatment of seasonal or perennial allergic rhinitis and accompanying nasal congestion:
Oral dosage:
Adults, the elderly, and adolescents >= 12 years: 1 tablet (cetirizine 5 mg and pseudoephedrine 120 mg extended-release) PO up to twice a day as needed, with doses given 12 hours apart. Elderly patients are more likely to have reduced renal function and adverse reactions to cetirizine; pseudoephedrine.
Children < 12 years: Safe and effective use of this fixed-dose combination product has not been established.
Maximum Dosage Limits:
Adults: 10 mg/day PO cetirizine and 240 mg/day PO pseudoephedrine.
Elderly: 10 mg/day PO cetirizine and 240 mg/day PO pseudoephedrine.
Adolescents >= 12 years: 10 mg/day PO cetirizine and 240 mg/day PO pseudoephedrine.
Children < 12 years: Not recommended.
Patients with hepatic impairment:
No more than 1 tablet (cetirizine 5 mg and pseudoephedrine 120 mg extended-release) PO once daily for hepatically-impaired adults and adolescents >= 12 years.
Patients with renal impairment:
CrCl >= 32 ml/min: No dosage adjustment needed.
CrCl <= 31 ml/min: No more than 1 tablet (cetirizine 5 mg and pseudoephedrine 120 mg extended-release) PO once daily for renally-impaired adults and adolescents >= 12 years.
Intermittent hemodialysis:
Follow dosage recommendations as for CrCl <= 31 ml/min; cetirizine is not removed by hemodialysis. The effect of hemodialysis on the removal of extended-release pseudoephedrine is unknown; however, 38% of immediate-release pseudoephedrine is removed by hemodialysis. Supplemental dosing is not needed.
[ Last revised: 8/22/2005 4:45:00 PM ]
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