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Xenical (Orlistat) Administration
Oral Administration
- Orlistat is administered orally with each main meal containing fat; if a meal is missed by the patient or the meal contains no fat, that dose of orlistat may be omitted.
- Patients should be on a reduced-calorie diet with approximately 30% of the calories from fat. Protein, carbohydrate, and fat intake should be balanced over 3 main meals.
- Orlistat may decrease the absorption of some fat-soluble vitamins (A, D, E, K) and beta-carotene. To ensure adequate nutrition, patients should take a multivitamin supplement that contains fat-soluble vitamins. The multivitamin supplement should be taken orally once per day at least two hours before or after the administration of orlistat (i.e. bedtime).
† non-FDA approved
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