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Vaniqa (Eflornithine) Administration
Topical Administration (Vaniqa™ cream)
- For topical use only. To reduce hair growth in facial and chin areas only. Do not apply to areas surrounding the eyes or to mucous membranes (e.g., mouth, nose, pubic area, etc.).
- The patient should continue to use hair removal techniques as needed; eflornithine is not a depilatory. Topical eflornithine should be applied >= 5 minutes after hair removal.
- Cosmetics or sunscreens may be applied over treated areas after the cream has dried.
Intravenous Administration (not commercially available in the US)
- For intravenous infusion only. Eflornithine injection is hypertonic and must be diluted with sterile water for injection prior to IV infusion administration.
- Solutions within 10% of plasma tonicity can be prepared by using 1 part eflornithine injection to 4 parts sterile water for injection, by volume. For example, to prepare four 5000 mg doses (usual trypanosomiasis dose for 50 kg patient): withdraw 100 ml from the eflornithine 200 mg/ml vial, then inject 25 ml (5 g) into each of four 100 ml (sterile water) IV diluent bags. The resulting eflornithine concentration will be 40 mg/ml (5000 mg per 125 ml total volume) in each IV bag.
- Store unopened vials at room temperature, 15-30 degrees C (59-86 degrees F). After mixing, the injection solution can be stored at 4 degrees C (39 degrees F) for up to 24 hours.
- Administer each dose by IV infusion over a period of at least 45 minutes.
†non-FDA approved
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Syndicate
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