Tretinoin, ATRA Administration
Tretinoin, ATRA Administration
Oral Administration
The effects of food on tretinoin bioavailability are unknown. The manufacturer makes no specific recommendations on oral administration of tretinoin, however, the absorption of retinoids as a class is enhanced by food.
Females of childbearing potential must use two reliable forms of contraception simultaneously during oral tretinoin therapy and for one month following discontinuation of therapy, unless abstinence is the chosen method. Within one week of beginning tretinoin oral therapy, the patient should have a negative pregnancy test; if possible, treatment with tretinoin should be delayed until the results of the pregnancy test are known. Pregnancy testing and counseling should occur monthly during oral tretinoin therapy.
Acute promyelocytic leukemia (APL) patients are considered high risk and administration of oral tretinoin may result in severe adverse reactions. Administration of tretinoin to these patients should be done only under the supervision of physicians experienced in the treatment of acute leukemia, and at a facility equipped to manage such adverse reactions, including respiratory compromise. It should be determined prior to the initiation of treatment that the benefit of therapy outweighs the risks to the patient.
Topical Administration
Topical tretinoin is a dermal irritant; the dermatologic response to greater than 48 weeks of chronic therapy is not known.
Before applying topical formulations of tretinoin, clean affected area with a mild soap, pat skin dry and wait 20 - 30 minutes before applying the product.
Cream: Rub cream gently into the affected area. Avoid over-application. Wash hands immediately after applying.
Solution: Apply using clean fingertips, a gauze pad, or cotton swabs to the cleansed affected area. Avoid over-saturation of gauze or cotton to prevent the solution from running onto unaffected areas. Wash hands immediately after applying.
Gel: Apply lightly to the affected area. Excessive application results in pilling of the gel. Wash hands immediately after applying.
Microsphere gel: Apply lightly to the affected area. Excessive application results in caking of the gel. Wash hands immediately after applying.
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Tretinoin, ATRA Monitoring Parameters
CBC with differential
LFTs
pregnancy testing
serum cholesterol profile
serum lipid profile
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Chemical Structure For: Tretinoin, ATRA
[ Last revised: 2/10/2005 9:46:00 AM ]
Related entries
- Tretinoin, ATRA
- Tretinoin, ATRA capsules
- Tretinoin, ATRA skin cream, liquid, or gel
- Tretinoin, ATRA Interactions
- Tretinoin, ATRA Indications and Dosage
- Tretinoin, ATRA Contraindications and Precautions
- Tretinoin Liposomal
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