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Tetracycline Administration

Oral Administration


  • Food and/or milk interferes with absorption of tetracycline. Take on an empty stomach (i.e., at least one hour prior to or two hours after a meal and/or milk) with plenty of fluids.
  • Divalent and trivalent cations significantly affect tetracycline absorption. Do not administer sucralfate (contains aluminum), oral iron supplements, or aluminum-, magnesium- or calcium-containing antacids with or within 4 hours of oral tetracycline. Multivitamins containing manganese or zinc salts will also decrease absorption of tetracycline.
  • To reduce the risk of esophageal irritation or ulceration, tetracycline should not be administered at bedtime or to patients with esophageal obstruction or compression.

Periodontal Administration (Actisite® Periodontal Fibers)


  • Fibers should be in contact with the base of the pocket and should be filled in to closely approximate the anatomy of the pocket.
  • An appropriate cyanocrylate adhesive should be used to secure the fiber in place.
  • If fibers are lost before 7 days after insertion, fibers should be replaced.
  • Instruct patient on actions to avoid to prevent dislodging fibers.

Ophthalmic Administration


  • Apply topically to the eye taking care to avoid contamination. For ophthalmic use only.
  • Instruct patient on proper instillation of eye ointment or solution.
  • Do not to touch the tip of the dropper or tube to the eye, fingertips, or other surface.
  • The ointment may be applied at night in combination with daytime use of the solution or before application of an eye patch.

Topical Administration


  • Reconstitution of powder for solution: Insert plastic applicator unit containing the powder into the bottle containing the diluent. By pressing firmly on the center of the applicator top, release powder into the liquid.
  • Apply solution by tilting bottle and rubbing the applicator top over the skin while gently applying pressure. Flow rate is determined by increasing or decreasing pressure on the skin. Apply generously until skin is thoroughly wet.

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