Skelaxin Interactions
Anxiolytics, Sedatives, and Hypnotics
Barbiturates
- Buprenorphine
- Butorphanol
- Dronabinol, THC
- Ethanol
- food
- Kava Kava, Piper methysticum
- Nalbuphine
Opiate agonists
- Pentazocine
Phenothiazines
Sedating H1-blockers
- Tramadol
Tricyclic antidepressants
- Valerian, Valeriana officinalis
Skelaxin Interactions
Concomitant administration of metaxalone with barbiturates, ethanol, and other CNS depressants can potentiate the sedative effects of either agent. Other CNS depressants include anxiolytics, sedatives, and hypnotics; opiate agonists; buprenorphine; butorphanol; nalbuphine; pentazocine; phenothiazines; dronabinol, THC, sedating H1-blockers; tricyclic antidepressants; tramadol; and the phytomedicinal herbs valerian, Valeriana officinalis or kava kava, Piper methysticum.
Administering metaxalone with food may increase the risk of common drug-related side effects after administration and may result in a decreased duration of drug effect. Administration of metaxalone with a high-fat meal increases the mean Cmax and AUC to 177.5% and 123.5%, respectively. In addition, the mean terminal half-life is substantially decreased following administration of the drug with a high-fat meal.
[ Last revised: 12/8/2005 1:08:00 PM ]
References
. Dantrium (dantrolene sodium) package insert. Mason, OH: Proctor & Gamble Pharmaceuticals; 2002 Sept.
. German Commission E. Kava Kava, Piperis methystici rhizoma, monograph Published June 1, 1990. In: Blumenthal, M et al ., eds. The complete German Commission E Monographs -Therapeutic Guide to Alternative Medicines. Boston MA: Integrative Medicine Communications for the American Botanical Council; 1998:156 - 7.
. Seixas FA. Alcohol and its drug interactions. Ann Intern Med 1975;83:86 - 92.
. Charney DS, Mihic SJ, Harris RA. Hypnotics and sedatives. Gilman AG, Hardman JG, Limbird LE, (eds.) In: Goodman and Gilman’s The Pharmacological Basis of Therapeutics. 10th ed., New York, McGraw-Hill Companies. 2001:399 - 427.
. Fleming M, Mihic SJ, Harris RA. Ethanol. Gilman AG, Hardman JG, Limbird LE, (eds.) In: Goodman and Gilman’s The Pharmacological Basis of Therapeutics. 10th ed., New York, McGraw-Hill Companies. 2001:429 - 445.
. Skelaxin® (metaxalone) package insert. Bristol, TN: King Pharmaceuticals, Inc.; 2003 Aug.
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