Skelaxin Interactions

Anxiolytics, Sedatives, and Hypnotics
Barbiturates

Buprenorphine
Butorphanol
Dronabinol, THC
Ethanol
food
Kava Kava, Piper methysticum
Nalbuphine
Opiate agonists
Pentazocine
Phenothiazines
Sedating H1-blockers
Tramadol
Tricyclic antidepressants
Valerian, Valeriana officinalis

Skelaxin Interactions

Concomitant administration of metaxalone with barbiturates, ethanol, and other CNS depressants can potentiate the sedative effects of either agent. Other CNS depressants include anxiolytics, sedatives, and hypnotics; opiate agonists; buprenorphine; butorphanol; nalbuphine; pentazocine; phenothiazines; dronabinol, THC, sedating H1-blockers; tricyclic antidepressants; tramadol; and the phytomedicinal herbs valerian, Valeriana officinalis or kava kava, Piper methysticum.

Administering metaxalone with food may increase the risk of common drug-related side effects after administration and may result in a decreased duration of drug effect. Administration of metaxalone with a high-fat meal increases the mean Cmax and AUC to 177.5% and 123.5%, respectively. In addition, the mean terminal half-life is substantially decreased following administration of the drug with a high-fat meal.

[ Last revised: 12/8/2005 1:08:00 PM ]

References
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. German Commission E. Kava Kava, Piperis methystici rhizoma, monograph Published June 1, 1990. In: Blumenthal, M et al ., eds. The complete German Commission E Monographs -Therapeutic Guide to Alternative Medicines. Boston MA: Integrative Medicine Communications for the American Botanical Council; 1998:156 - 7.

. Seixas FA. Alcohol and its drug interactions. Ann Intern Med 1975;83:86 - 92.

. Charney DS, Mihic SJ, Harris RA. Hypnotics and sedatives. Gilman AG, Hardman JG, Limbird LE, (eds.) In: Goodman and Gilman’s The Pharmacological Basis of Therapeutics. 10th ed., New York, McGraw-Hill Companies. 2001:399 - 427.

. Fleming M, Mihic SJ, Harris RA. Ethanol. Gilman AG, Hardman JG, Limbird LE, (eds.) In: Goodman and Gilman’s The Pharmacological Basis of Therapeutics. 10th ed., New York, McGraw-Hill Companies. 2001:429 - 445.

. Skelaxin® (metaxalone) package insert. Bristol, TN: King Pharmaceuticals, Inc.; 2003 Aug.

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