Skelaxin Contraindications and Precautions
- anemia
- hemolytic anemia
- hepatic disease
- renal impairment
- breast-feeding
- children
- driving or operating machinery
- elderly
- pregnancy
Skelaxin Contraindications and Precautions
According to the manufacturer, metaxalone is contraindicated in patients with significant renal impairment or hepatic dysfunction (hepatic disease). The drug is also contraindicated in patients with a history of drug-induced hemolytic anemia or other types of anemia.
Metaxalone is a CNS depressant. Patients should be cautioned about driving or operating machinery until the effects of the drug are known.
Metaxalone is not advised for use in the elderly due to the potential for anticholinergic side effects, sedation, and weakness. The effectiveness of metaxalone at doses tolerated in the geriatric population is questionable.
No FDA pregnancy category is available for metaxalone. Reproduction studies in rats revealed no evidence of impaired fertility or harm to the fetus due to metaxalone. Adequate and well-controlled studies have not been conducted in pregnant women. Metaxalone should only be used during pregnancy if the potential benefits outweigh the possible risk to the fetus.
It is not known if metaxalone is distributed into human milk. Thus, metaxalone should be used with caution in a woman who is breast-feeding.
Safety and effectiveness of metaxalone have not been established in children 12 years of age or younger.
[ Last revised: 12/8/2005 1:08:00 PM ]
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