Ranitidine Administration
Oral Administration
- All oral dosage forms: May be administered without regard to meals. May administer with food, water, or milk to minimize
gastric irritation.
- EFFERdose® tablets: Dissolve 150 mg dose in 6 - 8 ounces (180 - 240 ml) of water before administration; dissolve the 25 mg dose in
no less than 5 ml of water in an appropriate measuring cup. Once the EFFERdose® tablet is completely dissolved, the solution
may be administered to the patient. The solution may be administered by medicine dropper for infants. EFFERdose® tablets should not be chewed, swallowed whole, or dissolved on the tongue.
- Syrup: Measure dosage with calibrated oral syringe or cup prior to administration to give an accurate dosage.
Parenteral Administration
- Ranitidine injection is administered via the intramuscular or intravenous routes.
- Pharmacy bulk vial package is only available for preparing admixtures; the pre-mixed infusion bags are only for slow
intravenous-infusion administration.
- Visually inspect parenteral products for particulate matter and discoloration prior to administration whenever solution and
container permit.
Intramuscular injection:
- No dilution necessary.
- Inject into a large muscle mass. Aspirate prior to injection to avoid injection into a blood vessel.
Intermittent direct IV injection:
- Dilute to a maximum of 2.5 mg/ml using non-preserved NS or other compatible IV solution. For example, a 50 mg dose should be
diluted to 20 ml.
- Inject at a rate no greater than 4 ml/minute (i.e., 50 mg/20 ml dose should be pushed over 5 minutes).
Intermittent IV infusion:
- Dilute to a maximum of 0.5 - 1 mg/ml using D5W, NS, or other compatible IV solution. The diluted solution is stable for up to 48
hours at room temperature.
- Pre-mixed ready-to-use infusion bags are available as 1 mg/ml ranitidine (i.e., 50 mg/50 ml). Premixed ready-to-use bags are
for slow IV administration only.
- Infuse over 15 - 20 minutes (5 - 7 ml/minute).
Continuous 24-hour IV infusion:
- For adults, dilute 150 mg of ranitidine in 250 ml of D5W or NS or another compatible solution. The diluted solution is stable
for up to 48 hours at room temperature. Infuse over 24 hours at a rate of 6.25 mg/hr or as specified by physician.
- Use a controlled-rate infusion device.
- Alternatively, the dosage may be added to a compatible TPN solution for administration over 24 hours.
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Ranitidine Monitoring Parameters
- intragastric pH: in critically-ill patients
- LFTs: baseline
- serum creatinine/BUN: baseline
- stool guaiac: in critically-ill patients
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Chemical Structure For: Ranitidine
[ Last revised: 7/8/2005 3:14:00 PM ]
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