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Prochlorperazine suppositories

What are prochlorperazine suppositories?
PROCHLORPERAZINE helps to control severe nausea and vomiting. Generic suppositories are available.

What should I tell my health care provider before I take this medicine?
They need to know if you have any of these conditions:


  • blood disorders or disease
  • difficulty passing urine
  • glaucoma
  • liver disease or jaundice
  • Parkinson’s disease
  • pheochromocytoma
  • prostate trouble
  • seizures (convulsions)
  • uncontrollable movement disorder
  • an unusual or allergic reaction to prochlorperazine, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?
Prochlorperazine suppositories are put into the rectum (back passage). Do not take by mouth. Wash your hands. Take off the foil wrapping. Wet the tip of the suppository with water to make it easier to use. Lie on your side and raise your knee to your chest. Using your finger, gently push the suppository into the rectum. Hold it in place for a few minutes. Wash your hands. Use your doses at regular intervals. Do not use your medicne more often than directed.

Contact your pediatrician or health care professional regarding the use of this medicine in children. Special care may be needed.

Elderly patients over age 65 years may have a stronger reaction to this medicine and need smaller doses.

What if I miss a dose?
If you miss a dose, use it as soon as you can. If it is almost time for your next dose, use only that dose. Do not use double or extra doses.

What drug(s) may interact with prochlorperazine?


  • alcohol
  • bromocriptine
  • dofetilide
  • lithium
  • medicines for movement abnormalities as in Parkinson’s disease, or for gastrointestinal problems
  • medicines for pain
  • seizure (convulsion) or epilepsy medicine

Tell your prescriber or health care professional about all other medicines you are taking, including non-prescription medicines, nutritional supplements, or herbal products. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check with your health care professional before stopping or starting any of your medicines.

What side effects may I notice from using prochlorperazine?
Side effects that you should report to your prescriber or health care professional as soon as possible:


  • blurred vision
  • breast enlargement in men or women
  • breast milk in women who are not breast-feeding
  • chest pain, fast or irregular heartbeat
  • confusion, restlessness
  • dark yellow or brown urine
  • difficulty breathing or swallowing
  • dizziness or fainting spells
  • drooling, shaking, movement difficulty (shuffling walk) or rigidity
  • fever, chills, sore throat
  • involuntary or uncontrollable movements of the eyes, mouth, head, arms, and legs
  • menstrual changes
  • seizures (convulsions)
  • sexual difficulties (decreased sexual desire or impotence)
  • slurred speech
  • stomach area pain
  • sweating
  • unusual weakness or tiredness
  • unusual bleeding or bruising
  • yellowing of skin or eyes

Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome):


  • constipation
  • difficulty passing urine
  • difficulty sleeping
  • drowsiness
  • dry mouth
  • headache
  • increased sensitivity to the sun or ultraviolet light
  • nasal congestion
  • skin rash, or itching
  • weight gain

What should I watch for while taking prochlorperazine?
Visit your prescriber or health care professional for regular checks on your progress. Do not stop using prochlorperazine suddenly; this can cause nausea, vomiting, and dizziness. Ask your prescriber or health care professional for advice if you are to stop using this medicine.

If the suppository is too soft to use, hold it under cold running water or put in the refrigerator for 30 minutes before you remove the foil wrapping.

You may get drowsy, dizzy, or have blurred vision. Do not drive, use machinery, or do anything that needs mental alertness until you know how prochlorperazine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol can increase possible dizziness or drowsiness. Avoid alcoholic drinks.

Prochlorperazine can reduce the response of your body to heat or cold. Try not to get overheated. Avoid temperature extremes, such as saunas, hot tubs, or very hot or cold baths or showers. Dress warmly in cold weather.

Prochlorperazine can make your skin more sensitive to sun or ultraviolet light. Keep out of the sun, or wear protective clothing outdoors and use a sunscreen (at least SPF 15). Do not use sun lamps or sun tanning beds or booths. Wear sunglasses to protect your eyes.

Your mouth may get dry, chewing sugarless gum or sucking hard candy and drinking plenty of water will help.

Do not treat yourself for coughs, colds, sore throat, or allergies. Ask your prescriber or health care professional for advice.

If you are going to have surgery, tell your prescriber or health care professional that you are using prochlorperazine.

Where can I keep my medicine?
Keep out of the reach of children in a container that small children cannot open.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused medicine after the expiration date.

[ Last Revised: 9/21/2006 10:20:00 AM ]

NOTE: This information is not intended to cover all possible uses, precautions, interactions, or adverse effects for this drug. If you have questions about the drug(s) you are taking, check with your health care professional.

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