Prochlorperazine Indications and Dosage
- anxiety
- migraine †
- nausea/vomiting
- schizophrenia
† non-FDA-approved indication
Prochlorperazine Indications and Dosage
For preoperative nausea control:
Intramuscular dosage:
Adults: 5 - 10 mg IM given 1 to 2 hours before induction of anethesia, repeated once in 30 minutes if necessary.
Intravenous dosage:
Adults: 5 - 10 mg IV given 15 to 30 minutes before induction of anesthesia, repeated once if necessary, or add 20 mg to a liter of dextrose 5%/NS 0.9% solution 15 to 30 minutes before induction. The maximum parenteral dosage is 40 mg/day.
For the control of severe nausea/vomiting:
- for the treatment of nausea and vomiting in adults:
Oral dosage (immediate-release tablets or syrup):
Adults: 5 - 10 mg PO 3 - 4 times per day.
Oral dosage (sustained-release capsules):
Adults: 10 or 15 mg PO every 12 hours.
Rectal dosage (rectal suppositories):
Adults: 25 mg PR twice per day.
Intravenous or Intramuscular dosage:
Adults: 5 - 10 mg IV or IM repeated every 3 - 4 hours prn. The maximum parenteral dose is 40 mg/day.
- for the treatment of nausea and vomiting in children:
Oral or rectal dosage (immediate-release tablets, oral syrup)
Children 2 - 12 years (weight 18 to 39 kg): 2.5 mg PO three times per day; or 5 mg PO twice per day (max: 15 mg/day).
Children 2 - 12 years (weight 14 to 17 kg): 2.5 mg PO 2 - 3 times per day (max: 10 mg/day).
Children 2 - 12 years (weight 9 to 13 kg): 2.5 mg PO once per day or twice per day (max: 7.5 mg/day).
Children < 2 years of age and infants (weight < 9 kg): Dosage not established.
Rectal dosage (pediatric rectal suppositories):
Children 2 - 12 years (weight 18 to 39 kg): 2.5 mg PR three times per day; or 5 mg PR twice per day (max: 15 mg/day).
Children 2 - 12 years (weight 14 to 17 kg): 2.5 mg PR 2 - 3 times per day (max: 10 mg/day).
Children 2 - 12 years (weight 9 to 13 kg): 2.5 mg PR once per day or twice per day (max: 7.5 mg/day).
Children < 2 years of age and infants (weight < 9 kg): Dosage not established.
Intramuscular dosage:
Children 2 - 12 years (weight 18 to 39 kg): 0.132 mg/kg deep IM injection given 3 - 4 times per day, not to exceed 10 mg/day on the first day of treatment (max: 15 mg/day on subsequent days).
Children 2 - 12 years (weight 14 to 17 kg): 0.132 mg/kg deep IM injection given 3 - 4 times per day (max: 10 mg/day).
Children 2 - 12 years (weight 9 to 13 kg): 0.132 mg/kg deep IM injection given 3 - 4 times per day (max: 7.5 mg/day).
Children < 2 years and infants (weight < 9 kg): Dosage not established.
For the management of the manifestations of psychotic disorders such as schizophrenia:
Oral dosage:
Adults, (outpatients): 5 - 10 mg PO 3 - 4 times/day.
Adults, (hospitalized or severly disturbed): 10 mg PO 3 - 4 times/day. Use lower initial dosage for elderly. This dosage is then increased every 2 or 3 days until symptoms are controlled, or adverse effects become intolerable. Dosages up to 150 mg/day have been required in some severly disturbed patients.
Children 6 - 12 years: 2.5 mg PO 2 - 3 times/day; do not exceed 10 mg/day on the first day. May increase after first day, as needed and tolerated up to a maximum of 25 mg/day, in divided doses.
Children 2-5 years: 2.5 mg PO 2 - 3 times/day; do not exceed 10 mg/day on the first day. May increase after first day, as needed and tolerated up to a maximum of 20 mg/day, in divided doses.
Children < 2 years and infants (weight < 9 kg): Dosage not established.
Intramuscular dosage:
Adults: 10 - 20 mg IM initially, repeated every 1 - 4 hours as necessary to control symptoms. Convert to oral dosage as soon as possible.
Children 2 - 12 years: 0.132 mg/kg as a single dose IM; do not exceed 10 mg/day on the first day of therapy, convert to oral dosage as soon as possible.
Children < 2 years and infants (weight < 9 kg): Dosage not established.
For the short-term treatment of non-psychotic anxiety:
Oral dosage:
Adults: 5 - 10 mg PO 3 - 4 times/day.
Rectal dosage † :
Adults: 25 mg PR every 12 hours.
For the treatment of intractable, severe migraine † unresponsive to other therapies, or prior to administration of intravenous dihydroergotamine (DHE) to offset DHE-induced nausea:
Intravenous or Intramuscular dosage:
Adults: 10 mg via IM or via slow IV injection over 2 minutes.
Maximum Dosage Limits:
- Adults: 50 mg/day PR, 40 mg/day PO, or 40 mg/day IM.
- Elderly: 50 mg/day PR, 40 mg/day PO, or 40 mg/day IM.
- Adolescents: 50 mg/day PR, 40 mg/day PO, or 40 mg/day IM.
- Children 6 - 12 years (weight 18 - 39 kg): 15 mg/day PO or PR for nausea/vomiting; 25 mg/day PO for psychotic disorders.
- Children 6 - 12 years (weight 14 - 17 kg): 10 mg/day PO or PR for nausea/vomiting; 25 mg/day PO for psychotic disorders.
- Children 2 - 5 years (weight 18 - 39 kg): 15 mg/day PO or PR for nausea/vomiting; 20 mg/day PO for psychotic disorders.
- Children 2 - 5 years (weight 14 - 17 kg): 10 mg/day PO or PR for nausea/vomiting; 20 mg/day PO for psychotic disorders.
- Children 2 - 5 years (weight 9 - 13 kg): 7.5 mg/day PO or PR for nausea/vomiting; 20 mg/day PO for psychotic disorders.
- Children 2 - 5 years (weight < 9 kg): Safe and effective use has not been established.
- Children < 2 years: Safe and effective use has not been established.
- Infants: Safe and effective use has not been established.
Patients with hepatic impairment:
In general, phenothiazine-type medications should be used with caution; however, quantitative guidelines for dose adjustment in hepatic impairment are not available.
Patients with renal impairment:
Specific guidelines for dosage adjustments in renal impairment are not available; it appears that no dosage adjustments are needed.
† non-FDA-approved indication
[ Last revised: 9/21/2006 9:51:00 AM ]
Related entries
Syndicate
|
