|
 |
 |
|
 |
|
Prochlorperazine Administration
Oral administration
- Tablets or capsules: Administer with food, milk, or a glass of water to minimize gastric irritation. Administer extended-release products intact; should not be chewed or crushed.
- Oral syrup: May be diluted in citrus or chocolate-flavored drinks. NOTE: Oral liquid preparations of prochlorperazine are no longer available in the US.
Rectal administration
- Instruct patient on proper use of suppository (see Patient Information).
- Moisten the suppository with water prior to insertion. If suppository is too soft because of storage in a warm place, chill in the refrigerator for 30 minutes or run cold water over it before removing the wrapper.
Parenteral administration
- Prochlorperazine is administered by IM or IV injection or by IV infusion. Do not administer subcutaneously due to local irritation.
- Visually inspect parenteral products for particulate matter and discoloration. Prochlorperazine is a clear, colorless to pale yellow solution; a slight yellowish discoloration will not alter potency. Discard solution if markedly discolored.
- It is recommended that prochlorperazine injections not be mixed with other agents in the administration syringe.
- Storage: Store vials at 20 - 25 degrees C (68 - 77 degrees F). Do not freeze. Protect from light.
Intramuscular injection:
- No dilution necessary.
- Inject deeply into the outer upper quadrant of the buttock. Aspirate prior to injection to avoid injection into a blood vessel. Keep patient in recumbent position for at least 30 minutes following injection to minimize hypotensive effects.
Direct IV injection:
- No dilution necessary.
- Inject directly into a vein at a rate not exceeding 5 mg/minute. Do not give as a bolus injection. Monitor blood pressure during IV administration.
Intravenous infusion:
- Dilute 20 mg (4 ml) in 1 liter of a compatible IV infusion solution (e.g., NS injection).
- Infuse IV beginning 15 - 30 minutes before anesthesia induction. Monitor blood pressure during IV administration.
[ Last revised: 12/13/2006 10:38:00 AM ]
Related entries
Syndicate
|
|
|
