Pimecrolimus (Elidel) Interactions
Pimecrolimus (Elidel) Interactions
Potential interactions between pimecrolimus and other drugs, including vaccines, have not been evaluated. No drug interactions are expected; however, due to the very low blood levels of pimecrolimus detected in some patients, the possibility of drug interactions cannot be excluded. The concomitant administration of drugs known to be inhibitors of cytochrome P450 3A4 in patients receiving pimecrolimus for widespread and/or erythrodermic disease should be approached with caution.
A flushing syndrome (alcohol intolerance) has been reported in patients treated with topical tacrolimus or pimecrolimus upon ingestion of ethanol. The flushing occurred in the face or at the sites of medication application, usually within 5 - 15 minutes of ethanol ingestion, and lasted for an average duration of 1 hour. Patients describe redness and warm sensations, which sometimes result in discomfort. The reaction does not appear to occur in all patients; roughly 3 - 7% report a notable effect. The possible mechanism of the effect is the inhibition of acetaldehyde dehydrogenase, leading to increased acetaldehyde dehydrogenase concentrations in the skin. Aspirin appears useful in attenuation of the reaction in those patients for whom the reaction is bothersome.
[ Last revised: 3/15/2005 8:38:00 AM ]
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