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Phendimetrazine Indications and Dosage

  • obesity

    Phendimetrazine Indications and Dosage

    For the management of exogenous obesity as a short-term adjunct (a few weeks) in a regimen of weight reduction based on caloric restriction in patients with an initial body mass index (BMI) of 30 kg/m2 or higher and who have not responded to appropriate weight reducing regimen (diet and/or exercise) alone:
    NOTE: To limit unwarranted use and risks, phendimetrazine should be continued only if satisfactory weight loss occurs within the first 4 weeks of therapy (e.g., weight loss of at least 4 lbs, or as determined by the prescriber and patient).
    Oral dosage (regular capsules or tablets):
    Adults: 17.5-35 mg PO 2-3 times per day, 1 hour before meals.
    Children < 16 years: Not recommended.

    Oral dosage (extended-release capsules):
    Adults: 105 mg PO once daily, 30-60 minutes before breakfast.
    Children < 16 years: Not recommended.

    Maximum Dosage Limits:

  • Adults: 210 mg/day PO for regular-release formulations.
  • Elderly: 210 mg/day PO for regular-release formulations. May require reduced dosages compared to younger adults.
  • Adolescents >= 16 years: 210 mg/day PO for regular-release formulations.
  • Adolescents < 16 years: Safe and effective use has not been established.
  • Children: Safe and effective use has not been established.

    Patients with hepatic impairment:
    The effects of hepatic impairment on phendimetrazine are unknown; use with caution.

    Patients with renal impairment:
    Specific guidelines for dosage adjustment in renal impairment are not available; it appears that no dosage adjustments are needed.

    [ Last revised: 2/1/2002 ]

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