Ciclopirox (Penlac) Indications and Dosage
- Candida albicans
- candidiasis
- Epidermophyton floccosum
- Malassezia furfur
- Microsporum canis
- onychomycosis
- seborrheic dermatitis
- tinea corporis
- tinea cruris
- tinea pedis
- tinea versicolor
- Trichophyton mentagrophytes
- Trichophyton rubrum
Ciclopirox (Penlac) Indications and Dosage
For the topical treatment of mild to moderate onychomycosis of fingernails and toenails without lunula involvement, due to Trichophyton rubrum in immunocompetent patients:
NOTE: Penlac™ should be used in conjunction with a comprehensive management program for onychomycosis which includes removal of the unattached, infected nails (as frequently as monthly) by a health care professional and weekly trimming of the nails by the patient.
Topical dosage for Topical Nail Solution (Penlac™ 8% Nail Lacquer):
Adults and adolescents: Apply once daily (preferably at bedtime or eight hours before washing nails) to affected nails with the applicator brush provided. Ciclopirox should be applied evenly over the entire nail plate and 5 mm of surrounding skin. If possible, apply to the nail bed, hyponychium, and the under surface of the nail plate when it is free of the nail bed (e.g. onycholysis). Contact with the surrounding skin may produce mild, transient irritation (redness). Apply daily over the previous coat (do not remove nail lacquer until 7 days). Remove the nail lacquer coat every 7 days with alcohol. Patients should file away (with an emery board) loose nail material and trim nails, as required, every seven days after ciclopirox is removed with alcohol. Repeat this cycle throughout the duration of therapy. The safety and efficacy of using ciclopirox daily for > 48 weeks have not been established.
Elderly: See adult dosage.
Children: Safe and effective use has not been established.
For the topical treatment of seborrheic dermatitis of the scalp:
Topical dosage (Loprox® 1% shampoo):
Adults: Wet hair and apply roughly 1 teaspoon (5 ml) to the scalp. Up to 10 ml may be used for long hair. Lather and leave on hair and scalp for 3 minutes. Rinse off. Repeat treatment twice per week for a total of 4 weeks, with a minimum of 3 days between applications. If there is no improvement after 4 weeks of treatment, the diagnosis should be reviewed.
Elderly: See adult dosage.
Adolescents and children: Safe and effective use has not been established.
For the topical treatment of tinea corporis, tinea cruris, or tinea pedis (Epidermophyton floccosum; Microsporum canis; Trichophyton mentagrophytes; Trichophyton rubrum); tinea versicolor (Malassezia furfur); or cutaneous candidiasis due to Candida albicans:
Topical dosage (ciclopirox 0.77% cream, gel or lotion; and Loprox TS® topical suspension):
Adults, adolescents and children >= 10 years: Apply sparingly to affected skin and surrounding areas twice daily, morning and evening. Clinical improvement with relief of pruritus and other symptoms usually occurs within the first week of treatment. Re-evaluate patients who show no clinical improvement after 4 weeks. To avoid recurrence, patients with Candida albicans, tinea cruris, tinea corporis, and tinea versicolor should be treated for 2 - 4 weeks. Patients with tinea versicolor usually exhibit clinical and mycological clearing after 2 weeks of treatment. Tinea pedis should be treated for 4 weeks or longer to prevent recurrence.
Elderly: See adult dosage.
Children < 10 years, infants, and neonates: Safe and effective use has not been established.
Maximum Dosage Limits:
- Adults: No maximum dosage information is available.
- Elderly: No maximum dosage information is available.
- Adolescents: No maximum dosage information is available.
- Children >= 10 years: No maximum dosage information is available for Loprox®. Safe and effective use has not been established for Penlac™.
- Children < 10 years: Safe and effective use has not been established.
Patients with renal impairment:
No dosage adjustment is needed.
Patients with hepatic impairment:
No dosage adjustment is needed.
[ Last revised: 1/27/2005 6:22:00 PM ]
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