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Lansoprazole (Prevacid) Administration
Oral Administration
- All dosage forms: Administer dosage 30 minutes prior to meal whenever possible. A once-daily dosage is usually administered prior to breakfast. The presence of a meal in the stomach decreases the bioavailability by about 50%. Antacids were used concomitantly with lansoprazole in clinical trials.
- Delayed-release capsules: Swallow delayed-release capsules intact; do not chew or crush. For patients with difficulty swallowing, the capsules may opened and the contents may be sprinkled on 1 tablespoonful (15 ml) of either applesauce, Ensure® liquid supplement, pudding, yogurt, or cottage cheese. Do not crush the capsule contents into the food. Swallow immediately. Do not chew the medication. Do not prepare doses before the time of administration. Alternatively, the capsule may be emptied into a small volume of either apple juice, orange juice or tomato juice (60 ml, approximately 2 ounces), mixed briefly and swallowed immediately. To ensure complete delivery of the dose, the glass should be rinsed with two or more volumes of juice and the contents swallowed immediately. The granules have been shown in vitro to remain intact when exposed to apple, cranberry, grape, orange, pineapple, prune, tomato, and V-8 vegetable juice and stored for up to 30 minutes.
- Delayed-release oral suspension: Packets containing the enteric-coated granules (15 or 30 mg doses) are mixed with 2 tablespoonfuls (30 ml) of water to form a strawberry-flavored suspension, intended for immediate administration after mixing. Do not use with other liquids or foods. Stir well and drink immediately. Do not crush or chew the granules. If any material remains after drinking, add more water, stir, and drink immediately.
- Delayed-release disintegrating tablets: Place the Prevacid® SoluTab™ on the tongue and allow it to disintegrate until the particles can be swallowed. The tablet will disintegrate rapidly (< 1 minute). Do not chew the tablets. For administration via an oral syringe, the tablet can be dissolved in water (4 ml for 15 mg tablet, 10 ml for 30 mg tablet) and should be administered within 15 minutes.
- Patients with a nasogastric tube: Prevacid® capsules or disintegrating tablets can be administered via a nasogastric tube. Capsules: Open the capsule and mix the intact granules in 40 ml of apple juice and inject through the nasogastric tube into the stomach. After administering the granules, the nasogastric tube should be flushed with additional apple juice to clear the tube. Nasogastric tube: Dissolve tablet in water (4 ml for 15 mg tablet, 10 ml for 30 mg tablet) and administer within 15 minutes. After administration, the tube should be flushed to clear the tube.
Intravenous Administration
- Lansoprazole is administered as an intravenous (IV) infusion either through a dedicated line or a Y-site. The drug should NOT be given by IV push or other parenteral routes other than IV infusion.
- Administer IV using the in-line filter provided. The filter MUST be used to remove precipitate.
- Visually inspect parenteral products for particulate matter and discoloration prior to administration whenever solution and container permit.
Reconstitution of vial:
- Reconstitute each 30 mg vial with 5 ml of Sterile Water for Injection, USP only. NOTE: Lansoprazole IV must be reconstituted with 5 ml of Sterile Water for Injection, USP. Failure to reconstitute with Sterile Water may result in formation of precipitation/particulates.
- Mix gently by swirling. The resulting solution will contain lansoprazole 6 mg/ml.
- The reconstituted solution can be held for 1 hour when stored at 25 degrees C (77 degrees F) prior to further dilution.
- Reconstituted vials and admixtures do not need to be protected from light. Do not freeze.
Preparation and Administration of IV infusion:
- Dilute the reconstituted vial in either 50 ml of 0.9% Sodium Chloride Injection (NS), Lactated Ringer’s Injection (LR), or 5% Dextrose Injection (D5W). The admixture should be stored at 25 degrees C (77 degrees F). No refrigeration is required.
- If reconstituted with NS or LR, solution must be administered within 24 hours. If reconstituted with D5W, solution must be administered within 12 hours.
- Administer IV using the in-line filter provided. The filter MUST be used to remove precipitate.
- Lansoprazole IV infusion is administered either through a dedicated line or a Y-site. A dedicated line is not required; however, the intravenous line should be flushed before and after administration. When administered via a Y-site, immediately stop use if a precipitation or discoloration occurs.
- Infuse IV over 30 minutes.
- Do not administer lansoprazole IV with other drugs or diluents.
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Lansoprazole Monitoring Parameters
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Chemical Structure For: Lansoprazole
[ Last revised: 4/15/2005 2:21:00 PM ]
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