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Fluconazole (Diflucan) injection

What is fluconazole injection?
FLUCONAZOLE (Diflucan®) is an antifungal type of antibiotic. It treats serious fungal infections found throughout the body. These include oral candidiasis or thrush infections of the mouth or throat, candidal infection of the urinary tract, meningitis, and others. Generic fluconazole injections are available.

What should my health care professional know before I receive fluconazole?
They need to know if you have any of these conditions:


  • diabetes
  • heart disease
  • kidney disease
  • liver disease
  • other chronic illness
  • an unusual or allergic reaction to fluconazole; other azole medicines (used to treat yeast and other fungal infections); or other medicines, foods, dyes or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?
Fluconazole is for infusion into a vein. Finish the full course prescribed by your prescriber or health care professional even if you feel better. Do not stop using except on your prescriber’s advice.

What if I miss a dose?
If you miss a dose, use it as soon as you can. If it is almost time for your next dose, use only that dose. Do not use double or extra doses.

What drug(s) may interact with fluconazole?


  • bosentan
  • cilostazol
  • cisapride
  • cyclosporine
  • dofetilide
  • doxercalciferol
  • certain medicines for anxiety or difficulty sleeping
  • medicines for diabetes that are taken by mouth
  • medicines for high cholesterol such as atorvastatin, fluvastatin, lovastatin, or simvastatin
  • medicines for yeast or fungal infections
  • paricalcitol
  • phenytoin
  • pimozide
  • ramelteon
  • rifabutin
  • rifampin
  • tacrolimus
  • terfenadine
  • warfarin
  • water pills

Tell your prescriber or health care professional about all other medicines you are taking, including non-prescription medicines, nutritional supplements, or herbal products. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check with your health care professional before stopping or starting any of your medicines.

What side effects may I notice from receiving fluconazole?
Stop taking this medication immediately and report these side effects to your prescriber or health care professional right away:


  • fainting or falling spells
  • irregular heartbeat, palpitations, or chest pain

Side effects that you should report to your prescriber or health care professional as soon as possible:


  • dark yellow or brown urine
  • dizziness
  • light-colored stools (bowel movements)
  • redness, blistering, peeling or loosening of the skin, including inside the mouth
  • skin rash, itching
  • stomach pain
  • unusual bruising or bleeding
  • yellowing of the eyes or skin
  • vomiting

Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome):


  • diarrhea
  • headache
  • loss of appetite or changes in how food tastes
  • nausea

What should I watch for while taking fluconazole?
Tell your prescriber or health care professional if your symptoms do not improve in a few weeks. Some fungal infections need many weeks or months of treatment to cure. Use your medicine regularly for as long as your prescriber or health care professional tells you to.

If you are using this medicine for a long time you must visit your prescriber or health care professional for regular blood and liver function tests.

Alcohol can increase possible damage to your liver. Do not take alcoholic drinks while you use this medicine.

Fluconazole has been associated with birth defects when given at high doses early in a pregnancy. If you are pregnant or think you may be pregnant, tell you prescriber or health care professional immediately. Women who may become pregnant should use effective birth control while taking fluconazole.

Where can I keep my medicine?
Keep out of the reach of children.

Store at room temperature between 5-25°C (41-77°F); do not freeze. Keep container tightly closed. Throw away any unused medicine after the expiration date.

[ Last Revised: 8/31/2005 3:00:00 PM ]

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