xerostomia
Cyclobenzaprine Adverse Reactions
Adverse reactions most commonly reported with cyclobenzaprine use, resulting from CNS depression and/or anticholinergic response, are drowsiness (39%), xerostomia (27%), and dizziness (11%). Reactions that were reported in between 1% and 3% of patients taking cyclobenzaprine include: fatigue/tiredness, asthenia, nausea/vomiting, constipation, dyspepsia, dysgeusia, blurred vision, headache, nervousness, and confusion. Other less frequently reported side effects include: malaise, sinus tachycardia, cardiac arrhythmias, potential for QT prolongation at higher doses or overdosage based on similar structure to tricyclic antidepressants, a case report of torsades de pointes with concurrent droperidol, vasodilation, palpitation, hypotension, vomiting, diarrhea, GI pain, gastritis, thirst, flatulence, swollen tongue, abnormal liver-function tests, cholestatic jaundice, angioedema, pruritus, urticaria, rash, ataxia, vertigo, tremors, seizures (convulsions), muscle twitching, disorientation, hallucinations, excitement, paresthesia, diplopia, anxiety, depression, sweating, and tinnitus. Elderly patients are at higher risk for adverse CNS (e.g. hallucinations, confusion) and cardiac events, potentially leading to falls or other sequelae.
[ Last revised: 4/25/2004 3:33:00 PM ]
References
. Douglass MA, Levine DP. Hallucinations in an elderly patient taking recommended doses of cyclobenzaprine. Arch Intern Med 2000; 160:1373.
. Flexeril® (cyclobenzaprine) package insert. Fort Washington, PA: McNeil Consumer & Specialty Pharmaceuticals; 2003 Feb.
. Michalets EL, Smith LK, Van Tassel ED. Torsade de pointes resulting from the addition of droperidol to an existing cytochrome P450 drug interaction. Ann Pharmacother 1998;32:761 - 5.
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