Cocaine Indications and Dosage
- local anesthesia
- mucosal anesthesia
- ophthalmic anesthesia †
† non-FDA-approved indication
Cocaine Indications and Dosage
For local anesthesia and/or mucosal anesthesia with vasoconstriction (especially in the oral, laryngeal, and nasal cavities) prior to instrumentation or surgical procedures:
Topical dosage (Topical solution, Viscous topical solution):
Adults: Apply 1 - 10% solution (most commonly, 4%) by means of cotton applicators, packs, sprays, or by instillation. Use the lowest effective dose. Do not exceed 1 mg/kg. In general, solutions greater than 4% are not recommended due to increased risk of systemic toxicity.
Elderly or debilitated patients and children >= 6 years: Reduced dosages may be necessary (see adult dosage).
Topical dosage (Crystals/Flakes):
Adults: Apply 400 mg (preweighed), or lowest effective dose, with moistened cotton-tipped applicator.
For ophthalmic anesthesia † :
NOTE: Topical solutions of cocaine intended for use in anesthetizing the mucous membranes of the oral, laryngeal, and nasal cavities are not intended for ophthalmic administration.
Ophthalmic dosage † (Ophthalmic solution † ):
Adults: Apply 1 - 4% solution by instillation.
Elderly or debilitated patients and children >= 6 years: Reduced dosages may be necessary (see adult dosage).
Maximum Dosage Limits:
- Adults: 1 mg/kg/dose topically.
- Elderly: 1 mg/kg/dose topically.
- Adolescents: 1 mg/kg/dose topically.
- Children >= 6 years: 1 mg/kg/dose topically.
- Children < 6 years: Safe and effective use has not been established.
- Infants: Safe and effective use has not been established.
Patients with hepatic impairment:
Specific guidelines for dosage adjustments in hepatic impairment are not available; it appears that no dosage adjustments are needed.
Patients with renal impairment:
Specific guidelines for dosage adjustments in renal impairment are not available; it appears that no dosage adjustments are needed.
† non-FDA-approved indication
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