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Azithromycin (Zithromax) Administration
Oral Administration
Azithromycin is administered orally.
Tablets:
May be taken with or without food. However, increased tolerability has been observed when the tablets are taken with food.
Oral suspension (Zithromax® 1 gram single-dose packet):
Do not use for administration of doses other than 1 gram.
Zithromax® for oral suspension may be taken with or without food per the manufacturer.
Mix the entire contents of the packet in 60 ml (approximately 2 ounces) of water. Administer the entire contents immediately, then add an additional 60 ml of water, mix and administer to assure complete administration of the dosage.
Oral suspension (immediate-release, bottles for reconstitution):
Zithromax® for oral suspension in the 100 mg/5ml or 200 mg/5 ml strengths may be taken with or without food per the manufacturer.
Reconstitute 300, 600, 900, or 1200 mg bottles with 9, 9, 12, or 15 ml, respectively, of water to provide concentrations of 100, 200, 200, or 200 mg per 5 ml, respectively.
After mixing, store suspension at 5 - 30 degrees C (41 - 86 degrees F) and use within 10 days.
Administer using a calibrated measuring device.
Oral suspension (extended release, bottle for reconstitution):
Zmax™ extended release oral suspension (2 grams azithromycin) should be taken as a single dose at least 1 hour before or 2 hours following a meal.
Constitute with 60 ml of water, replace cap, and shake bottle well.
The dry powder should be stored at or below 30 degrees C (86 degrees F). After mixing, store suspension at 15 - 30 degrees C (59 - 86 degrees F) and use within 12 hours.
Intravenous Administration
For intravenous infusion after dilution only; do not administer IM or via IV bolus.
Visually inspect parenteral products for particulate matter and discoloration prior to administration whenever solution and container permit.
Reconstitution:
NOTE: When using the Vial-Mate™ drug reconstitution device, please refer to the Vial-Mate™ instructions for assembly and reconstitution.
Add 4.8 ml of sterile water for injection to the 500-mg vial and shake until all of the drug is dissolved. Because the vial is supplied under vacuum, it is recommended that a standard 5 ml (non-automated) syringe be used to ensure that the exact amount of 4.8 ml of sterile water is dispensed.
The reconstituted solution contains 100 mg/ml azithromycin. The reconstituted solution is stable for 24 hours when stored below 30 degrees C (86 degrees F). Dilute further prior to administration.
Dilution:
To provide a concentration of 1 mg/ml azithromycin, transfer 5 ml of the 100 mg/ml reconstituted azithromycin solution into 500 ml of a compatible diluent. For a 2 mg/ml azithromycin infusion solution, use 250 ml of a compatible diluent.
Compatible diluents include: D5W, D5 in 0.45% NS (1/2 NS), D5 in 0.33% NS (1/3 NS), D5LR, D5 in 1/2 NS with 20 mEq KCl, NS, 1/2 NS, LR, Normosol®-M in D5W, and Normosol®-R in D5W.
Diluted solutions are stable for 24 hours at or below room temperature (30 degrees C or 86 degrees F) or for 7 days if stored under refrigeration (5 degrees C or 41 degrees F).
Intravenous infusion:
The infusion concentration and rate of infusion should be either 1 mg/ml over 3 hours or 2 mg/ml over 1 hour.
† non-FDA approved
Azithromycin (Zithromax) Monitoring Parameters
LFTs
Chemical Structure For: Azithromycin
[ Last revised: 6/15/2005 5:38:00 PM ]
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