Acetaminophen; Codeine Indications and Dosage
- arthralgia †
- bone pain †
- cough †
- dental pain †
- headache †
- migraine †
- mild pain
- moderate pain
- myalgia †
† non-FDA-approved indication
Acetaminophen; Codeine Indications and Dosage
For the treatment of mild pain to moderate pain including the relief of dental pain † (e.g., toothache), headache † , migraine † , back pain † , bone pain † , arthralgia † and myalgia † :
Oral dosage (tablets or capsules):
Adults: 1 - 2 tablets PO every 4 hours as needed. Maximum single dose of codeine is 60 mg/dose. Maximum dose of acetaminophen is 4 g/day.
Children: 0.5 - 1 mg codeine/kg PO every 4 - 6 hours. Dosage should be titrated to appropriate analgesic effect. Maximum acetaminophen dose is 75 mg/kg/day PO or 4 g/day PO, whichever is less.
Oral dosage (elixir or suspension):
Adults and children >= 12 years: 15 ml PO every 4 hours as needed. Maximum single dose of codeine is 60 mg/dose. Maximum dose of acetaminophen is 4 g/day.
Children 7 - 11 years: 10 ml PO three to four times per day as needed. Maximum acetaminophen dose is 75 mg/kg/day PO or 4 g/day PO, whichever is less.
Children 4 - 6 years: 5 ml PO three to four times per day as needed. Maximum acetaminophen dose is 75 mg/kg/day PO or 4 g/day PO, whichever is less.
Children >= 3 years: Dosage not established.
For the treatment of non-productive cough † :
Oral dosage:
Adults: 10 - 20 mg codeine PO every 4 - 6 hours as needed. Maximum codeine dose should not exceed 120 mg/24 hours when used as an antitussive and maximum acetaminophen dose is 4 g/day.
Children: 1 - 1.5 mg/kg/day codeine PO in divided doses every 4 - 6 hours as needed. Maximum acetaminophen dose is 75 mg/kg/day PO or 4 g/day PO, whichever is less. Alternatively, children 2 - 5 years of age can receive 2.5 - 5 mg codeine PO every 4 - 6 hours as needed (maximum codeine dose 30 mg/day when used as an antitussive) and children 6 - 12 years of age can receive 5 - 10 mg codeine PO every 4 - 6 hours as needed (maximum codeine dose 60 mg/day when used as an antitussive).
Maximum Dosage Limits:
NOTE: For combination products containing acetaminophen, total daily intake of acetaminophen from all sources should be considered and may be the dose-limiting consideration for acetaminophen; codeine products.
- Adults: Acetaminophen 4 g/day PO; codeine 60 mg/dose PO; some clinicians have recommended the following maximum dosages: for pain, codeine 360 mg/24 hours PO; as an antitussive, codeine 120 mg/day PO.
- Elderly: Acetaminophen 4 g/day PO; codeine 60 mg/dose PO; some clinicians have recommended the following maximum dosages: for pain, codeine 360 mg/24 hours PO; as an antitussive, codeine 120 mg/day PO.
- Adolescents: Acetaminophen 4 g/day PO; codeine 60 mg/dose PO; some clinicians have recommended the following maximum dosages: for pain, codeine 360 mg/24 hours PO; as an antitussive, codeine 120 mg/day PO.
- Children 6 - 12 years: Acetaminophen 75 mg/kg/day PO or 4 g/day PO, whichever is less; codeine 60 mg/dose PO; some clinicians have recommended a maximum dosage for codeine as an antitussive of 60 mg/day PO.
- Children < 5 years: Acetaminophen 75 mg/kg/day PO or 4 g/day PO, whichever is less; as an antitussive, some clinicians have recommended a maximum dosage for codeine as an antitussive of 30 mg/day PO.
Patients with hepatic impairment:
Dosage should be modified depending upon the clinical response and degree of hepatic impairment. No quantitative recommendations are available.
Patients with renal impairment:
Dosage should be modified depending upon the clinical response and degree of renal impairment. No quantitative recommendations are available.
† non-FDA approved indication
[ Last revised: 10/29/2003 4:55:00 PM ]
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