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Acetaminophen Administration

NOTE: Acute overdoses of acetaminophen are extremely toxic and potentially fatal. Do not exceed recommended daily dosage. In addition, ingestion of normal doses daily for many months has also been associated with hepatotoxicity and/or nephrotoxicity.

Oral Administration


  • All dosage forms: Administer with a full glass of water. May be taken without regard to meals.
  • Extended release tablets: Do not crush.
  • Oral solution: Administer using a calibrated measuring device.
  • Oral suspension: Shake well before administration. Administer using a calibrated measuring device.
  • Chewable tablets: May be swallowed whole or chewed.
  • Oral granules: Mix with a small amount of soft food (i.e., applesauce, ice cream, or jam) prior to administration.
  • Oral powders: Do not administer the capsules containing the powder whole. Open capsule and sprinkle over a small amount of water (>5 ml) or mix with a small amount of soft food (i.e., applesauce, ice cream, or jam) prior to administration.

Rectal Administration


  • Instruct patient on proper use of suppository (see Patient Information).
  • Moisten the suppository with water prior to insertion. If suppository is too soft because of storage in a warm place, chill in the refrigerator for 30 minutes or run cold water over it before removing the wrapper.
  • Suppository must be retained in rectum for at least 1 hour to ensure complete absorption.

[ Last revised: 5/12/2006 11:07:00 AM ]

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