How should I take tramadol?
Take tramadol exactly as it was prescribed for you. Do not take it in larger doses or for longer than recommended by your doctor. Follow the directions on your prescription label. Do not take more than 300 milligrams of tramadol in one day.
Take this medication with a full glass of water.
Tramadol can be taken with or without food, but take it the same way each time.
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What is tramadol?
Tramadol is a narcotic-like pain reliever.
Tramadol is used to treat moderate to severe pain. Tramadol extended-release is used to treat moderate to severe chronic pain when treatment is needed around the clock.
Tramadol may also be used for other purposes not listed in this medication guide.
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What should I avoid while taking tramadol?
Do not drink alcohol while you are taking tramadol. Alcohol may cause a dangerous decrease in your breathing when used together with tramadol.
Cold or allergy medicine, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression or anxiety can add to sleepiness caused by tramadol. Tell your doctor if you regularly use any of these other medicines.
Tramadol can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.
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What other drugs will affect tramadol?
You may be more likely to have a seizure (convulsions) if you take tramadol while you are using certain other medicines. Do not take tramadol without telling your doctor if you also use any of the following medications:
- an MAO inhibitor such as isocarboxazid (Marplan), tranylcypromine (Parnate), phenelzine (Nardil), or selegiline (Eldepryl, Emsam); or
- an antidepressant such as amitriptyline (Elavil), citalopram (Celexa), clomipramine (Anafranil), desipramine (Norpramin), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem), fluvoxamine (Luvox), imipramine (Tofranil), nortriptyline (Pamelor); paroxetine (Paxil), or sertraline (Zoloft).
Before taking tramadol, tell your doctor if you also use:
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What is the most important information I should know about tramadol?
You should not take tramadol if you have ever been addicted to drugs or alcohol.
Seizures (convulsions) have occurred in some people taking tramadol. You may be more likely to have a seizure while taking tramadol if you have a history of seizures or head injury, a metabolic disorder, or if you are taking certain medicines such as antidepressants, muscle relaxers, or medicine for nausea and vomiting.
Take tramadol exactly as it was prescribed for you. Do not take it in larger doses or for longer than recommended by your doctor. Do not take more than 300 milligrams of tramadol in one day.
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Tramadol: Pharmacology
tramadol: Pharmacology
Metabolism: liver extensively; CYP450: 2B6, 2D6, 3A4 substrate; Info: active metabolite
Excretion: urine (30% unchanged); Half-life: 6.3h (tramadol), 7.4h (metabolite)
Class: Other Analgesics
Mechanism Of Action
exact mechanism of action unknown; binds to mu opioid receptors and weakly inhibits norepinephrine/serotonin reuptake, producing analgesia (central opioid agonist)
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