Allopurinol tablets
What are Allopurinol (Zyloprim) tablets?
ALLOPURINOL (Lopurin®, Zyloprim®) reduces the amount of uric acid the body makes. Too much uric acid in the blood can cause damage and produce kidney stones and gout. Allopurinol (Zyloprim) will help to prevent gout, but will not ease an acute attack. It is also used to help prevent to decrease uric acid levels that occur as a result of some sorts of chemotherapy for certain types of leukemia, lymphoma or solid tumors. Generic Allopurinol (Zyloprim) tablets are available.
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Allopurinol injection
What is Allopurinol (Zyloprim) injection?
ALLOPURINOL (Aloprim™) reduces the amount of uric acid the body makes. During chemotherapy for certain types of leukemia, lymphoma or solid tumors, large amounts of uric acid may be formed. Too much uric acid in the blood can cause damage to your kidneys. Allopurinol (Zyloprim) will help to decrease the amount of uric acid and help to prevent damage to your kidneys during chemotherapy. Generic allopurinol injection is available.
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Allopurinol Interactions
- Aluminum Hydroxide
- Azathioprine
- Chlorpropamide
- Cyclosporine
- Dicumarol
- Fluorouracil, 5-FU
- Mercaptopurine, 6-MP
Photosensitizing Agents
- Rasburicase
- Theophylline, Aminophylline
Thiazide diuretics
- Warfarin
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Allopurinol Indications and Dosage
- gout
- hyperuricemia
- nephrolithiasis
- renal calculus
- uric acid nephropathy
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Allopurinol Contraindications and Precautions
- breast-feeding
- driving or operating machinery
- hepatic disease
- pregnancy
- renal disease
- renal failure
- renal impairment
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Allopurinol (Zyloprim) Adverse Reactions
- abdominal pain
- acute generalized exanthematous pustulosis (AGEP)
- aplastic anemia
- azotemia
- cataracts
- cholestasis
- diarrhea
- dyspepsia
- elevated hepatic enzymes
- exfoliative dermatitis
- gastritis
- glomerulonephritis
- hepatic necrosis
- hepatitis
- interstitial nephritis
- jaundice
- leukopenia
- maculopapular rash
- nausea/vomiting
- nephrolithiasis
- neutropenia
- purpura
- Stevens-Johnson syndrome
- toxic epidermal necrolysis
- urticaria
- vasculitis
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Allopurinol Monitoring Parameters
- LFTs: baseline if hepatic disease
- serum creatinine/BUN: baseline
- serum uric acid
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Allopurinol Administration
Oral Administration
- Allopurinol (Zyloprim) is administered after meals and with plenty of fluids.
- Maintain urine output of at least 2 L/day.
- An extemporaneous oral suspension may be prepared by crushing 2400 mg allopurinol and levigate with glycerin or distilled water. Add 40 ml methylcellulose (Cologel®); then add enough 2:1 simple syrup/cherry syrup mixture to obtain a total volume of 120 ml. The final concentration will be 20 mg/ml. Store in the refrigerator and shake well prior to use. The suspension is stable for 8 weeks.
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Allopurinol
Aloprima, Zyloprim®
Classification:
Musculoskeletal Agents
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