PROZAC

PROZAC® is a selective serotonin reuptake inhibitor indicated for:

• Acute and maintenance treatment of Major Depressive Disorder (MDD) in adult and pediatric patients aged 8 to 18 years (1.1)
• Acute and maintenance treatment of Obsessive Compulsive Disorder (OCD) in adult and pediatric patients aged 7 to 17 years (1.2)
• Acute and maintenance treatment of Bulimia Nervosa in adult patients (1.3)
• Acute treatment of Panic Disorder, with or without agoraphobia, in adult patients (1.4)

PROZAC and olanzapine in combination for:

• Acute treatment of Depressive Episodes Associated with Bipolar I Disorder in adults (1.5)
• Acute treatment of Treatment Resistant Depression in adults (Major Depressive Disorder in adult patients who do not respond to 2 separate trials of different antidepressants of adequate dose and duration in the current episode) (1.6)

Call your healthcare provider right away if you have any of the following symptoms, or call 911 if an emergency, especially if they are new, worse, or worry you:

• attempts to commit suicide
• acting on dangerous impulses
• acting aggressive or violent
• thoughts about suicide or dying
• new or worse depression
• new or worse anxiety or panic attacks
• feeling agitated, restless, angry or irritable
• trouble sleeping
• an increase in activity or talking more than what is normal for you
• other unusual changes in behavior or mood

Most common adverse reactions (≥5% and at least twice that for placebo) associated with:

Major Depressive Disorder, Obsessive Compulsive Disorder, Bulimia, and Panic Disorder: abnormal dreams, abnormal ejaculation, anorexia, anxiety, asthenia, diarrhea, dry mouth, dyspepsia, flu syndrome, impotence, insomnia, libido decreased, nausea, nervousness, pharyngitis, rash, sinusitis, somnolence, sweating, tremor, vasodilatation, and yawn (6.1)

PROZAC and olanzapine in combination – Also refer to the Adverse Reactions section of the package insert for Symbyax (6)