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ALDACTONE

Generic Name: spironolactone (spir ON oh LAK tone)
Brand Names: Aldactone
PRESCRIPTION: Yes
GENERIC AVAILABLE: Yes
PREPARATIONS: Tablets 25, 50, and 100 mg
STORAGE: Spironolactone should be stored at room temperature, below 25 C (77 F).

Aldactone is a potassium-sparing diuretic (water pill) that prevents your body from absorbing too much salt and keeps your potassium levels from getting too low.

Aldactone is used to diagnose or treat a condition in which you have too much aldosterone in your body. Aldosterone is a hormone produced by your adrenal glands to help regulate the salt and water balance in your body.

Aldactone also treats fluid retention (edema) in people with congestive heart failure, cirrhosis of the liver, or a kidney disorder called nephrotic syndrome. Aldactone is also used to treat or prevent hypokalemia (low potassium levels in the blood).

Aldactone may also be used for other purposes not listed in this medication guide.

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Aldactone tablets contain the active ingredient spironolactone, which is a type of medicine called a potassium-sparing diuretic. Diuretics are sometimes referred to as '‘water table'ts'. (NB. Spironolactone is also available without a brand name, ie as the generic medicine.)

Spironolactone works by blocking the actions of a hormone in the body called aldosterone. This hormone is produced by glands found above the kidneys called the adrenal glands. Aldosterone acts in the kidneys, where it is involved in controlling the balance of salt and water in the body.

Blocking the action of aldosterone causes the kidneys to increase the amount of salts such as sodium that they filter out of the blood and into the urine. When these salts are filtered out of the blood by the kidneys, water is also drawn alongside. Spironolactone therefore increases the amount of water that is drawn out of the blood and into the urine. This helps excess fluid to be removed from the body.

There are many conditions that can lead to an accumulation of fluid in the body (oedema). These include heart failure (where the fluid may build up in the lungs, causing breathlessness, or the ankles, causing swollen ankles), liver cirrhosis (where fluid may build up in the abdominal cavity, causing a swollen abdomen) and certain types of kidney disease. Spironolactone is used to remove excess fluid associated with these conditions and thus relieve the related symptoms.

Most other diuretics cause the amount of potassium in the blood to drop. Spironolactone doesn't have this effect, and so is called a 'potassium-sparing' diuretic. It is usually used in combination with other diuretics to increase the removal of fluid from the body, while preventing potassium levels from falling too low.

Spironolactone is also used in the treatment of a condition called Conn's syndrome, in which there is excess production of aldosterone by the adrenal glands. By opposing the action of aldosterone, spironolactone relieves the symptoms of this syndrome, which include fluid retention, high blood pressure and low levels of potassium in the blood.